Avascular Necrosis and

Bone Degeneration

If you are suffering from Avascular necrosis (AVN), you may have one or more of the following symptoms:

  • Pain in your hip region, knee and groin
  • Pain when you put weight in the affected joint
  • Pain when lying down
  • Limited movement with the affected joint
  • Limp while walking

What happens when you

Have AVN?

AVN is a progressive bone condition caused by lack of blood supply to the bone tissue. Normally, blood vessels supply oxygen and nutrition to the bone.

  • Blocked vessels hinder the blood supply and the bone tissue starts to decay.
  • AVN mostly affects the hip joint (femoral head), although the knee, shoulder, ankle and other regions are also affected.

Stages of Avascular Necrosis of the Hip Joint

Stages I and II of AVN are early stages and symptoms usually start from Stage II. It is important to diagnose and seek treatment for AVN AS EARLY AS POSSIBLE as it progresses very rapidly. AVN is reversible when appropriate treatment is sought in its early stages.


In late stages III and IV, significant bone fractures and cartilage damage renders the joint non-functional. A stage IV AVN joint needs to be replaced by Total Hip Replacement surgery.


Root cause of AVN tackled to stop disease progression

Eliminates need for highly invasive Total Hip Replacement

Natural treatment – uses patients’ own cells

Bone Cell Therapy – Treatment

Bone marrow of the patient is extracted

Healthy bone cells (osteoblasts) are isolated and cultured in the laboratory

Cultured bone cells are implanted into the region of dead bone

Outcome of Bone Cell Therapy

New healthy bone replaces lost bone tissue

Progression of AVN is stopped

Original hip joint preserved

Patient can resume active normal life

Patient is free of pain and disability

Cartilage Damage and Osteochondral Defects

If you are suffering from cartilage injuries, you may be having one or more of the following symptoms:

  • Joint pain – at rest and when putting weight on the affected joint
  • Swelling around the affected joint
  • Joint stiffness
  • Clicking or grinding sensation
  • Joint locking or catching

What happens when you have Cartilage Damage?

Cartilage damage occurs due to excessive activity of joints, sports injury, accidents or trauma and even ageing. The most affected joint is the knee joint (picture), followed by shoulder, ankle, elbow and wrist.

  • Injured cartilage does not heal itself as cartilage does not have blood supply.
  • If left untreated, cartilage damage will worsen with time and lead to early onset of osteoarthritis (usually within 5-6 years after cartilage injury)

Stages of Cartilage Damage

Stages I and II of cartilage damage are early stages. Once cartilage gets damaged, in its place fibrous cartilage (a very poor form of the actual cartilage – hyaline cartilage) is formed. Fibrous cartilage has very poor mechanical strength.

Presence of fibrous cartilage makes the joint susceptible to further injuries and it becomes very difficult to carry out normal activities like walking, running, yoga and sports. Reduced physical activity will lead to diseases associated with sedentary lifestyle such as diabetes, obesity, hypertension and cardiovascular disorders.

A stage IV arthritic joint needs to be replaced by Total Knee Replacement surgery.


Eliminates need for Total Knee Replacement

Natural treatment – uses patients’ own cells

Minimally invasive arthroscopic procedure

Cartilage Cell therapy – Treatment

Healthy cartilage is extracted from the patient

Cartilage cells (chondrocytes) are cultured and expanded in the laboratory

Cultured chondrocytes are then implanted into the region of cartilage damage

Outcome of Cartilage Cell Therapy

New hyaline cartilage is regenerated at the defect sire

Progression of cartilage damage is stopped

Full range of motion of the joint is restored

Original knee joint is preserved

Patient is free of pain and disability

Patient returns to active normal life and sports activities